Peter Lundberg

Magnetresonsfysik: fMRI, MR-Spektroskopi och MR-Tomografi

Disputerade med avhandlingen “Multinuclear Nuclear Magnetic Resonance Spectroscopy Studies of Plant Metabolism” (June 1989) University of Calgary, Canada, supervisor Professor Hans J Vogel (University of Calgary, Canada), external examiner Professor Charles S. Springer (State University of New York, U.S.A.).

Tekn Lic (Lund, Sweden) 1985, avhandling “NMR Studies of Living Cells”.
Civ ing (Lund, Sweden) 1983, avhandling “Blod och kött, en NMR-studie i rött”.

Forskarutbildning

Magnetic Resonance Physics Course (MRPC); Echo Planar Imaging Course (EPIC); Advanced Magnetic Resonance Applications Course (AMRAC); Spin-Dynamics Course (SDC); School of In Vivo Magnetic Resonance Relaxation (SIMON); Scandinavian Magnetic Resonance Physics Course (SMRPC).
 

Forskningsområde

Medicinska och biologiska tillämpningar av Magnetresonansfysik

• Metoder för funktionell MRI (fMRI, avbildning av hjärnans funktion)
• Metoder för multinukleär Magnetresonansspektroskopi (MRS, mätning av vävnadsmetabolism)
• Metoder för kvantitativ Magnetresonanstomografi (MRI = MRT)
   

Projekt

• Bestämning av språklaterialisering med hjälp av fMRI
• Databas för singel och multidimensionell MRS (MDL)
• Hjärnaktivering vid meditation
• Hjärnfunktion hos patienter med afasi
• Hjärnfunktion hos patienter med IBS
• Ickeinvasiv biopsi av lever med hjälp av MRI och MRS
• Kvantifiering av fett i människa med hjälp av qMRI
• Kvantitativ MRI och kvantitativ modellering av kontrastdynamik i lever och gallvägar
• Metabolism och hjärnfunktion i patienten med KLS
• Metoder för kvantitativ MRI (qMRI) i hjärna
• Metoder för kvantitativ qMRI i lever och buk
• MRS av hjärnmetabolismen hos behandlade MS-patienter
• MRS av hjärnmetabolismen hos patienter med negativ MRI
• MRS av hjärnmetabolismen hos patienter med NPH
• Mycket snabb insamling av 3D MRI för fMRI
• Språkfunktion med hjälp av fMRI
• Table-top metod för karakterisering av multinukleära detektionsspolar
• Utveckling av databas för MR-säkerhet (SMRLink)

Medarbetare

Ida Blystad, Olof Dahlqvist Leinhard, Anders Tisell, Anders Grönkvist, Janne West, Helene Veenstra, Maria Magnusson, Rizwan Azhar, Bengt Norén, Mikael Forsgren

Peter Lundbergs publikationer i DiVA  (publikationsdatabas)

• Bergman, I, Lundberg, P, Nilsson, M (1999) ”Microbial carbon mineralisation in an acid surface peat: effects of environmental factors for laboratory incubations.", Soil Biol and Biochem, 31, 1867–1872.
• Bergman, I, Lundberg, P, Preston, CM, Nilsson, M (2000) ”Degradation of [U-13C]-glucose in Sphagnum majus litter: responses to different redox, pH and temperature conditions." Soil Sci Soc Am J, 64, 1368–1381.
• Dudman, NPD, Wilcken, DEL, Wang, J, Lynch, JF, Macey, D, Lundberg, P (1993) "Disordered methionine/homocysteine metabolism in premature vascular disease — its occurence, cofactor therapy and enzymology.” Arteriosclerosis and Thrombosis , 13, 1253–1260.
• Engström, M., Ragnehed, M., Lundberg, P, Söderfeldt, B. (2004) (Review) ”Paradigm design of sensory motor and language tests in clinical fMRI.” Clinical Neurophysiology, 34: 267-277.
• Friman, O, Borga, M, Lundberg, P, Knutsson, H (2003) “Adaptive analysis of fMRI data.”, NeuroImage, 19:837-845.
• Friman, O, Borga, M, Lundberg, P, Knutsson, H (2004) ”Detection and detrending in fMRI data analysis”, NeuroImage, 22: 645-655.
• Friman, O, Cedefamn, J, Lundberg, P, Borga, M, Knutsson, H (2001) “Detection of neural activity in functional MRI using Canonical Correlation Analysis.”, Magn Reson Med , 45, 323–330.
• Germann M W, Kalisch, B W, Lundberg P, Vogel HJ, van de Sande JH (1990) "Perturbation of DNA hairpins containing the EcoR1 recognition site by hairpin loops of varying size and composition: physical (NMR and UV) and enzymatic (EcoR1) studies", Nucleic Acids Res., 18, 1489–1498.
• Gustavsson, M., Dahlqvist, O., Jaworski, J., Lundberg, P., Landtblom, A-M, (2007) Low Choline in normal appearing white matter of patients with multiple sclerosis and normal MRI brain scans, Am J Neuroradiol, 28(7):1306-12.
• Hansson T, Nyman T, Björkman A, Lundberg P, Nylander L, Rosén B, Lundborg G (2009) Sights of touching activates the somatosensory cortex in humans, Scand J Plast Reconstr Surg Hand Surg 43(5): 267-269.
• Kechagias, S., Ernersson, Å., Dahlqvist, O., Lundberg, P., Lindström, T., Nyström, F. (2008) “Fast food based hyper-alimentation can induce rapid and profound elevations of serum aminotransferase levels in healthy subjects.”, Gut, 57: 649 - 654.
• Labotka, RJ, Lundberg, P and, Kuchel, PW (1995) "Ammonia permeability of the erythrocyte membrane studied by 14N and 15N saturation transfer NMR spectroscopy", Am J Physiol 268 (Cell Physiology 37):C686 - C699.
• Lundberg, P, and Kuchel, PW (1997) "Diffusion of solutes in agarose and alginate gels: 1H and 23Na PFGSE and 23Na TQF NMR studies". Magn Reson Med, 37, 44–52.
• Lundberg, P, Berners-Price, SJ, Roy, S and Kuchel, PW (1992) "NMR Studies of erythrocytes immobilized in agarose and alginate gels." Magn Reson in Med. 25, 273–288.
• Lundberg, P, Ekblad, A and Nilsson, M (2001) 13C NMR spectroscopy studies of forest soil microbial activity: glucose uptake and fatty acid biosynthesis.", Soil Biol and Biochem, 33, 621–632.
• Lundberg, P, Harmsen, E, Ho, C and Vogel, HJ (1990) (Invited review) "Nuclear magnetic resonance studies of cellular metabolism", Anal. Biochem. 191, 193–222.
• Lundberg, P, Roy, S, Kuchel, PW (1994) (Invited Review) "Immobilization methods for NMR studies of cellular metabolism - A practical guide.” ImmunoMethods, 4, 163–178.
• Lundberg, P, Roy, S., Kuchel, PW (1994) "Fructose 3-phosphate and phosphoribosylpyrophosphate formation in perfused human erythrocytes: 31P NMR studies" Magn Reson Med, 31, 110–121.
• Lundberg, P, Vogel, HJ and Rudérus, H (1986) "Carbon-13 and proton NMR studies of postmortem metabolism in bovine muscles", Meat Science, 18, 133–160.
• Lundberg, P, Vogel, HJ, Drakenberg, T, Forsén, S, Amiconi, G, Forlani, L, Chiancone, E (1989) "A 35Cl-NMR study of the singular anion-binding properties of dromedary hemoglobin", Biochim. Biophys. Acta 999, 12–18.
• Lundberg, P, Vogel, HJ, Fabiansson, S and Rudérus, H (1987) "Phosphorus-31 NMR studies of postmortem metabolism in fresh porcine, ovine and frozen bovine muscles" , Meat Science, 19, 1-14.
• Lundberg, P, Weich, R G, Jensén, P and Vogel, HJ (1989) "Phosphorus 31 and Nitrogen-14 NMR studies of the uptake of phosphorus and nitrogen compunds in the marine macroalgae Ulva lactuca", Plant. Physiol. 89, 1380–1387.
• McIntyre, DD, Apblett, A., Lundberg, P, Schmidt, K and Vogel, HJ (1989) "Nitrogen-14 NMR of dissolved dinitrogen: relaxation and reorientation behaviour", J Magn. Reson. 83, 377–382.
• Noren, B, Lundberg, P, Ressner, M, Wirell, S, Almer, S, Smedby, Ö (2005) ”Absolute quan-tification of human liver metabolite concentrations by localized in vivo 31P NMR spectroscopy – with respect to diffuse liver disease.”, Eur J Radiol, 15: 148 - 157.
• Noren, B., Dahlqvist, O., Lundberg, P, Almer, S., Kechagias, S., Ekstedt, M., Franzen, L., Wirell, S., Smedby, Ö. (2007) ”Separation of advanced from mild fibrosis in diffuse liver disease using 31P magnetic resonance spectroscopy.”, Eur J Radiol Jul 21 Epub, 2008 66(2):313-20.
• Ragnehed M, Engstrom M, Knutsson H, Soderfeldt B, Lundberg P. Restricted canonical correlation analysis in functional MRI-validation and a novel thresholding technique. J Magn Reson Imaging. 2009 Jan;29(1):146-54.
• Ragnehed M, Leinhard OD, Pihlsgard J, Wirell S, Sokjer H, Fagerstam P, et al. Lundberg, P. (2009) Visual grading of 2D and 3D functional MRI compared with image-based descriptive measures. Eur Radiol. 2009 Sep 2.
• van Ettinger-Veenstra HM, Ragnehed M, Hällgren, M, Karlsson, T, Landtblom, A-M, Lundberg P, Engström M, Right-hemispheric brain activation correlates to language performance, NeuroImage, 2009 Oct 21 [Epub].
• Warntjes, M., Dahlqvist, O., Lundberg, P. (2007) Novel Method for Rapid, Simultaneous T1, T*2, and Proton Density Quantification, Magn Reson Med, 57: 528-537.
• Warntjes, M., Dahlqvist, O., West, J., Lundberg, P. (2008) “Rapid magnetic resonance quantification on the brain: Optimization for clinical usage.”, Magn Reson Med, 60: 320-329.