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Fredrik Nystrom

Research Profile

Fredrik Nystrom became specialist in Endocrinology in 1994 and in internal medicine in 1996. He defended his phD thesis on ambulatory blood pressure and components of the metabolic syndrome in a population in 1997. Between 1997 and 1999 he was postdoc at NIH, NHLBI, in Bethesda MD, and learnt molecular biology from his tutor M J Quon (1). After his return to Sweden in 1999 he adapted the transfection technique he learnt at NIH in order to transfect primary human fat cells instead of primary rat fat cells, and several molecular biological papers were published in which this technique was used (2; 3). His first three PhD students all worked with this technique to transfect primary human fat cells in their thesis projects, Karin Stenkula (later on postdoc at NIH, NIDDK, in Bethesda S Cushman), Lilian Sauma and Niclas Franck (4) (later on postdoc at Karolinska Institute, J Zierath).

Fredrik Nystrom launched a study of fast food based hyper-alimentation in 2006 and 11 papers have been published with data from this rather extreme trial (exampels: 5-7), in which participants gained on average 10% of body weight during 4 weeks. A follow up study demonstrated that hyper-alimentation corresponding to addition of 20 kcal/kg/day for two weeks increased insulin and cholesterol levels if it was based on candy (sugar), but increased basal metabolic rate only in the group randomized to peanuts (protein and fat) (8). More recent life-style studies include a randomized study of three months in which participants were assigned either to complete alcohol abstention or to drink one (women) or two glasses (men) of wine/day. This study found minimal effects of alcohol on hepatic triglyceride content while LDL-cholesterol levels dropped 10% (Kechagias et al. Annals of medicine, 2011, epubl May 24). Data on incorproration of ethylglucuronide in hair have also been published (Kronstrand et al. Forensic Science International 2011 Feb 28.) and constitute a new method to assess long-term alchol intake in humans.

Fredrik Nystrom continues to work with epidemiology and cardiovascular risk factors and just published a paper in JAMA demonstrating that a high systolic blood pressure when admitted to the intensive care unit is linked with a low one- and three- year mortality rate (9). One of his main clinical studies on the same topic is the CARDIPP trial in which all 761 participants now are being reinvestigated after 4 years. CARDIPP is an acronym for Cardiovascular Risk Factors in Patients with Diabetes -a Prospective Study in Primary Care, and all participants have type 2 diabetes and are 55-65 years old. All participants have undergone an extensive investigation including laboratory analyses, cardiac ultrasonography, a recording of 24-hour ambulatory blood pressure (10), measurement of the carotid, femoral and radial pulse pressures and calculation of central blood pressure and pulse wave velocity. Also the intima-media thickness of the carotid arteries has been measured. The CARDIPP trial is run in a team including prof. T Länne, prof. CJ Östgren, ass. prof. T Lindström and ass. prof . J Engvall from the department of Medical and Health Sciences at Linköping University.

Fredrik Nystrom and his former PhD student Hans Guldbrand MD (et al.) have finished a randomized study of a low-fat compared with high-fat intake (low carb- LCHF) in patients with type 2 diabetes. Three papers have been published from this trial, demonstrating better glycaemic control and less need for insulin, less inflammation and improved quality of life by the low-carohydrate diet as compared with the traditional low-fat diet. Fredrik has also recently shown that fruit does not increase the metabolic rate as much as nuts do in a randomized trial (Agebratt et al. PLOS ONE 2015). Nystrom has also specifically studied if exposure to cold for about one hour a day increases metabolism and volume of the "heat organ" brown-adipose tissue. In collaboration with CMIV and colleagues in Gothenburg, it was indeed found that subjects who followed the "cool-protocol" displayed enlargement of supraclavicular brown adipose tissue volumes as measured with magnetic resonance imaging (in press, Metabolism). Also, subjects who had been randomized to avoid to freeze, lowered their metabolic rate.


Fredrik Nystroms publications in DiVA (publication database).

Selected publications, referenses

  1. Nystrom FH, Chen H, Cong LN, Li Y, Quon MJ. Caveolin-1 interacts with the insulin receptor and can differentially modulate insulin signaling in transfected Cos-7 cells and rat adipose cells. Mol Endocrinol 1999; 13: 2013-2024
  2. Stenkula KG, Said L, Karlsson M, Thorn H, Kjolhede P, Gustavsson J, Soderstrom M, Stralfors P, Nystrom FH. Expression of a mutant IRS inhibits metabolic and mitogenic signalling of insulin in human adipocytes. Mol Cell Endocrinol 2004; 221: 1-8
  3. Sauma L, Franck N, Paulsson JF, Westermark GT, Kjolhede P, Stralfors P, Soderstrom M, Nystrom FH. Peroxisome proliferator activated receptor gamma activity is low in mature primary human visceral adipocytes. Diabetologia 2007; 50: 195-201
  4. Franck N, Stenkula KG, Ost A, Lindstrom T, Stralfors P, Nystrom FH. Insulin-induced GLUT4 translocation to the plasma membrane is blunted in large compared with small primary fat cells isolated from the same individual. Diabetologia 2007; 50: 1716-1722
  5. Kechagias S, Ernersson A, Dahlqvist O, Lundberg P, Lindstrom T, Nystrom FH. Fast-food-based hyper-alimentation can induce rapid and profound elevation of serum alanine aminotransferase in healthy subjects. Gut 2008; 57: 649-654
  6. Erlingsson S, Herard S, Dahlqvist Leinhard O, Lindstrom T, Lanne T, Borga M, Nystrom FH. Men develop more intraabdominal obesity and signs of the metabolic syndrome after hyperalimentation than women. Metabolism 2009; 58: 995-1001
  7. Kos K, Wong S, Tan B, Gummesson A, Jernas M, Franck N, Kerrigan D, Nystrom FH, Carlsson LM, Randeva HS, Pinkney JH, Wilding JP. Regulation of the fibrosis and angiogenesis promoter SPARC/osteonectin in human adipose tissue by weight change, leptin, insulin, and glucose. Diabetes 2009; 58: 1780-1788
  8. Claesson AL, Holm G, Ernersson A, Lindstrom T, Nystrom FH. Two weeks of overfeeding with candy, but not peanuts, increases insulin levels and body weight. Scand J Clin Lab Invest 2009; 69: 598-605
  9. Stenestrand U, Wijkman M, Fredrikson M, Nystrom FH. Association between admission supine systolic blood pressure and 1-year mortality in patients admitted to the intensive care unit for acute chest pain. JAMA 2010; 303: 1167-1172
  10. Wijkman M, Lanne T, Engvall J, Lindstrom T, Ostgren CJ, Nystrom FH. Masked nocturnal hypertension--a novel marker of risk in type 2 diabetes. Diabetologia 2009; 52: 1258-1264

Fredrik Nystrom
Name: Fredrik Nyström
Position: Professor in Internal medicine
Department: Department of Medical and Health Sciences - IMH
Division: Cardiovascular Medicine


E-mail: fredrik.nystrom@regionostergotland.se

Visiting address:
University Hospital
South Entrance, elevator B, floor 12
Campus US

Linköping University
Internal Medicine
Division of Cardiovascular Medicine

Medical Research at LiU
Research in diabetes and metabolism
Research in heart and blood vessels

Page manager: malin.strand@liu.se
Last updated: Wed Apr 13 10:33:46 CEST 2016